Andy Cook became the first Tranmere player to reach 20 league goals in a single season for over a decade as he helped fire Rovers back to winning ways.
Many have tried and failed to reach such a landmark since Simon Haworth in 2002/03, with James Norwood, Chris Greenacre and Ryan Lowe all finishing a campaign on 19.
But Cook ensured he would not be another nearly man as his powerful second half header, as well as a first career hat-trick for Jay Harris, earned the three points.
It was always going to be important for Tranmere to end their four match winless run here as they looked to bounce back from Saturday’s FA Trophy defeat to Macclesfield.
With their Wembley dreams shattered, that result left Rovers heartbroken, but they could not let such pain derail a much more important promotion campaign.
They showed impressive character though in a game where Scott Davies had very little do.
Micky Mellon made one change following Saturday’s defeat, with Adam Mekki replaced by Ritchie Sutton as Tranmere went back to a 3-5-2 formation.
There was also a welcome return to the bench for Liverpool loanee Jack Dunn, absent for a month due to a hamstring injury.
This was Tranmere’s first trip to North Ferriby, a quaint little village hidden away near Hull.
Coach Shaun Garnett actually revealed pre-match that he had been here before, many years ago for a Tranmere reserve team again Hull’s second string.
He will not have been so shocked by the surroundings then, with the ground’s sole four row stand on the opposite side of the pitch to the club house.
The visitors started well, with James Norwood forcing an early save from Rory Watson as he got a foot on Connor Jennings’ bobbling effort, but the ‘keeper was able to readjust and tip wide.
They were soon behind though as centre-back Mark Gary gave his side the lead with a booming header.
It all stemmed from Michael Ihiekwe giving away a free-kick near the corner flag, and the defender found himself unmarked to nod home from close range from the resulting set-piece.
Sutton had a chance to make amends quickly for Rovers, but he could only head over from Jeff Hughes’ deep free-kick.
Tranmere were seeing most of the ball and, much like in their last few games, it was just a case of whether they could create the opportunities needed to score.
Thankfully they equalised with their next meaningful attack as Ihiekwe picked out Cook, who in turn fed to Jay Harris.
The midfielder drove forward five yards before slamming emphatically into the bottom corner from the edge of the penalty area.
Tranmere now had the bit between their teeth and Harris hit the post just a few minutes later as his shot from the 20-yards clipped a defender before brushing the woodwork.
Cook and Norwood had a couple of half chances over the next few minutes, but struggled to truly test the ‘keeper.
And then as the half drew to a close, the latter was again involved as Rovers were presented with a golden opportunity to take the lead.
The striker was brought down in the box as the hosts struggled to deal with a corner, and the referee immediately pointed to the spot.
Jeff Hughes stepped up to take it and although his kick was saved, Harris followed up to power home the rebound.
North Ferriby actually started brightly in the second half, winning several corners and having a penalty appeal for a challenge by Ihiekwe turned down.
But Tranmere struck on the hour when Cook headed home his 20th of the season.
The move started thanks to Steve McNulty winning an excellent tackle as the hosts threatened to counter-attack.
The ball fell to Harris who played Norwood own the right wing, and his pin-point cross was met unmarked by Cook at the back post.
With the game now looking safe, Micky Mellon took the opportunity to give his two strikers a rest, with Andy Mangan and Cole Stockton both coming on.
From then, Rovers saw the game out pretty comfortably, and even had a couple of further chances to extend their lead.
Sutton headed one over from a Hughes corner, whilst Mangan’s mazy run ended in a miss-hit shot which went harmlessly high and wide.
At the other end, Davies finally had another save to make when substitute Sam Cosgrove struck straight at him from nearly the penalty spot.
It was Tranmere who had the final say though as Harris completed his first career hat-trick by tapping home after being teed up by Mekki.